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Table 1 Comparison of numerical variables according to the presence of HFI

From: Hyperostosis frontalis interna and association of disease control with frontal bone thickness in acromegaly

Numerical Variable

Group 1 (n = 23)

HFI absent

Group 2 (n = 29)

HFI present

Total (n = 52)

p

Median (min.-max.)

Age (year)

56 (30–83)

59 (24–82)

58 (24–83)

0.412

Age at diagnosis (year)

44 (24–75)

44 (21–74)

44 (21–75)

0.775

Duration of

follow-up (month)

96 (12–252)

120 (6-408)

108 (6-408)

0.184

 

X (± SD)

p

FBTfirst(mm)

7.30 (1.80)

10.04 (3.10)

8.82 (2.93)

0.001

FBTlast(mm)

7.21 (1.64)

11.17 (3.13)

9.42 (3.24)

< 0.001

PBTfirst(mm)

6.09 (1.81)

6.78 (1.84)

6.48 (1.84)

0.128

PBTlast(mm)

6.33 (1.68)

7.57 (2.29)

7.02 (2.11)

0.025

OBTfirst(mm)

5.86 (1.64)

6.77 (2.16)

6.37 (1.98)

0.092

OBTlast(mm)

6.06 (1.34)

7.33 (2.26)

6.77 (2.00)

0.028

FPG (mg/dL)

112.78 (21.21)

122.68 (44.26)

118.30 (35.97)

0.978

HbA1c (%)

6.14 (0.77)

6.39 (1.54)

6.28 (1.26)

0.832

IGF-1first(ng/mL)

476.73 (215.89)

580.51 (296.67)

534.61 (266.72)

0.281

IGF-1last(ng/mL)

186.63 (82.07)

207.30 (98.87)

198.16 (91.60)

0.549

GH (ng/mL)

1.21 (1.25)

1.45 (2.07)

1.35 (1.75)

0.652

Prolactin (ng/mL)

8.18 (7.34)

8.88 (7.78)

8.57 (7.52)

0.541

Cortisol (µg/dL)

9.43 (5.47)

9.80 (5.78)

9.64 (5.59)

0.768

  1. HFI: hyperostosis frontalis interna FBT: Frontal bone thickness PBT: Parietal bone thickness OBT: Occipital bone thickness FPG: Fasting plasma glucose IGF-1: Insulin-like growth factor 1 GH: Growth hormone