Table 2 Odds ratios of smoking-related unweighted and weighted and GRSs derived from SNPs satisfying MR assumptions 1 and 3 for association between smoking and metabolic syndrome
From: Relationship between tobacco smoking and metabolic syndrome: a Mendelian randomization analysis
| Â | Â | Smoking | Metabolic syndrome | ||||
|---|---|---|---|---|---|---|---|
Variables | n | Yes, n (%) | Crude OR (95% CI) | Adjusted OR (95%CI) | Yes, n (%) | Crude OR (95% CI) | Adjusted OR (95%CI) |
Unweighted genetic risk score | |||||||
 Per standard deviation | 80,072 | 21,399 (26.72) | 1.08 (1.06, 1.09)*** | 1.08 (1.06, 1.11)*** | 15,773 (19.70) | 1.01 (0.99, 1.03) | 1.00 (0.98, 1.02) |
 Q1: < 10 | 21,569 | 5421 (25.13) | 1.00 | 1.00 | 4240 (19.66) | 1.00 | 1.00 |
 Q2: 10 | 13,928 | 3643 (26.16) | 1.06 (1.01, 1.11)* | 1.06 (1.00, 1.12) | 2700 (19.39) | 0.98 (0.93, 1.04) | 0.99 (0.93, 1.05) |
 Q3: 11–12 | 27,323 | 7299 (26.71) | 1.09 (1.04, 1.13)*** | 1.12 (1.06, 1.17)*** | 5461 (19.99) | 1.02 (0.98, 1.07) | 1.01 (0.96, 1.06) |
 Q4: ≥ 13 | 17,252 | 5036 (29.19) | 1.23 (1.17, 1.29)*** | 1.26 (1.19, 1.33)*** | 3372 (19.55) | 0.99 (0.94, 1.04) | 0.98 (0.92, 1.04) |
Weighted genetic risk score | |||||||
 Per standard deviation | 80,072 | 21,399 (26.72) | 1.08 (1.06, 1.09)*** | 1.08 (1.06, 1.11)*** | 15,773 (19.70) | 1.01 (0.99, 1.03) | 1.00 (0.98, 1.03) |
 Q1: < 0.30 | 20,016 | 5019 (25.07) | 1.00 | 1.00 | 3966 (19.81) | 1.00 | 1.00 |
 Q2: 0.30–0.33 | 20,020 | 5259 (26.27) | 1.07 (1.02, 1.11)** | 1.05 (1.00, 1.11) | 3877 (19.37) | 0.97 (0.93, 1.02) | 0.96 (0.91, 1.02) |
 Q3: 0.34–0.39 | 20,020 | 5304 (26.49) | 1.08 (1.03, 1.13)** | 1.09 (1.03, 1.15)** | 3999 (19.98) | 1.01 (0.96, 1.06) | 1.00 (0.95, 1.06) |
 Q4: ≥ 0.40 | 20,016 | 5817 (29.06) | 1.22 (1.17, 1.28)*** | 1.25 (1.18, 1.32)*** | 3931 (19.64) | 0.99 (0.94, 1.04) | 0.98 (0.93, 1.04) |