Relationship between tobacco smoking and metabolic syndrome: a Mendelian randomization analysis

BMC Endocrine Disorders

Table 3 Odds ratios of metabolic syndrome for predictive smoking derived from unweighted and weighted GRS

		Metabolic syndrome
Variables	n	Yes, n (%)	Crude OR (95% CI)	Adjusted OR (95%CI)¹	Adjusted OR (95%CI)²
Phat of smoking derived from unweighted genetic risk score
Per 1 standard deviation	80,072	15,773 (19.70)	1.62 (1.60, 1.65)***	1.63 (1.60, 1.65)***	1.49 (1.47, 1.52)***
Q1: < 0.16323	20,018	1997 (9.98)	1.00	1.00	1.00
Q2: 0.16323–0.21447	20,018	2364 (11.81)	1.21 (1.13, 1.29)***	1.21 (1.13, 1.29)***	1.16 (1.09, 1.24)***
Q3: 0.21448–0.29760	20,018	4189 (20.93)	2.39 (2.26, 2.53)***	2.38 (2.25, 2.52)***	2.17 (2.05, 2.30)***
Q4: ≥ 0.29761	20,018	7223 (36.08)	5.09 (4.82, 5.38)***	5.12 (4.85, 5.41)***	4.26 (4.02, 4.53)***
Phat of smoking derived from weighted genetic risk score
Per 1 standard deviation	80,072	15,773 (19.70)	1.62 (1.60, 1.65)***	1.63 (1.60, 1.65)***	1.49 (1.47, 1.52)***
Q1: < 0.16323	20,018	2006 (10.02)	1.00	1.00	1.00
Q2: 0.16323–0.21447	20,018	2351 (11.74)	1.20 (1.12, 1.27)***	1.20 (1.12, 1.27)***	1.15 (1.08, 1.22)***
Q3: 0.21448–0.29793	20,018	4204 (21.00)	2.39 (2.25, 2.53)***	2.38 (2.25, 2.52)***	2.17 (2.05, 2.30)***
Q4: ≥ 0.29794	20,018	7212 (36.03)	5.06 (4.79, 5.34)***	5.08 (4.81, 5.37)***	4.23 (3.98, 4.49)***

Adjusted odds ratio¹: adjusted for residual and PCA
Adjusted odds ratio²: adjusted for residual, PCA, and covariates that did not satisfy MR assumption 2
OR Odds ratio, CI Confidence interval, Q1 the first quartile, Q2 the second quartile, Q3 the third quartile, Q4 the fourth quartile
^*: P < 0.05
^**: P < 0.01
^***: P < 0.001

ISSN: 1472-6823