Table 2 Results of subgroup analysis based on different doses of vitamin D3 and treatment durations
| Â | Â | Â | Number of | Sample | Heterogeneity test results | Â | Â | |
|---|---|---|---|---|---|---|---|---|
Outcome | Method of grouping | Subgroup | studies | size | P-value | I2 Value | Effect model | Meta-analysis results |
Changes in fasting | Dose of Vitamin D3 | < 50,000 IU/week | 6 | 370 | 0.69 | 0 | Fixed | MD=-2.58, 95% CI (-4.47,- 0.68), P = 0.008 |
blood glucose |  | ≥ 50,000 IU/week | 5 | 214 | 0.04 | 60 | Random | MD=-3.65, 95% CI (-8.19,0.89), P = 0.12 |
|  | Treatment duration | < 12 weeks | 4 | 178 | 0.04 | 64 | Random | MD=-4.02, 95% CI (-8.63, 0.60), P = 0.09 |
|  |  | ≥ 12 weeks | 7 | 406 | 0.56 | 0 | Fixed | MD=-2.66, 95% CI (-4.55, -0.77), P = 0.006 |
Changes in insulin | Dose of Vitamin D3 | < 50,000 IU/week | 5 | 249 | 0.14 | 42 | Random | MD=-2.74, 95% CI (-5.09, -0.39), P = 0.02 |
|  |  | ≥ 50,000 IU/week | 5 | 214 | 0.40 | 1 | Fixed | MD=-1.16, 95% CI (-1.92, -0.39), P = 0.003 |
|  | Treatment duration | < 12 weeks | 4 | 178 | 0.31 | 15 | Fixed | MD=-1.09, 95% CI (-1.84, -0.33), P = 0.005 |
|  |  | ≥ 12 weeks | 6 | 285 | 0.41 | 1 | Fixed | MD=-3.13, 95% CI (-4.61, -1.65), P < 0.0001 |
Changes in | Dose of Vitamin D3 | < 50,000 IU/week | 5 | 249 | 0.71 | 0 | Fixed | MD=-16.16, 95% CI (-23.75,-8.58), P < 0.0001 |
triglycerides |  | ≥ 50,000 IU/week | 4 | 173 | 0.35 | 9 | Fixed | MD=-5.70, 95% CI (-13.40, 2.00), P = 0.15 |
|  | Treatment duration | < 12 weeks | 3 | 145 | 0.24 | 29 | Random | MD=-7.43, 95% CI (-17.93, 3.07), P = 0.29 |
|  |  | ≥ 12 weeks | 6 | 277 | 0.64 | 0 | Fixed | MD=-15.45, 95% CI (-22.93, -7.97), P < 0.0001 |
Changes in total | Dose of Vitamin D3 | < 50,000 IU/week | 5 | 249 | 0.42 | 0 | Fixed | MD=-14.69, 95% CI (-21.86, -7.53), P < 0.0001 |
cholesterol |  | ≥ 50,000 IU/week | 4 | 173 | 0.21 | 33 | Random | MD=-9.42, 95% CI (-15.77, -3.07), P = 0.004 |
|  | Treatment duration | < 12 weeks | 3 | 145 | 0.17 | 44 | Random | MD=-10.07, 95% CI (-16.95, -3.20), P = 0.004 |
|  |  | ≥ 12 weeks | 6 | 277 | 0.37 | 8 | Fixed | MD=-13.32, 95% CI (-20.14, -6.49), P = 0.0001 |
Changes in | Dose of Vitamin D3 | < 50,000 IU/week | 3 | 180 | 0.36 | 2 | Fixed | MD=-3.20, 95% CI (-4.75, -1.65), P < 0.0001 |
VLDL-cholesterol |  | ≥ 50,000 IU/week | 2 | 92 | 0.10 | 63 | Random | MD=-2.68, 95% CI (-7.73, 2.36), P = 0.30 |
|  | Treatment duration | < 12 weeks | 2 | 92 | 0.10 | 63 | Random | MD=-2.68, 95% CI (-7.73, 2.36), P = 0.30 |
|  |  | ≥ 12 weeks | 3 | 180 | 0.36 | 2 | Fixed | MD=-3.20, 95% CI (-4.75, -1.65), P < 0.0001 |
Changes in | Dose of Vitamin D3 | < 50,000 IU/week | 5 | 249 | 0.27 | 22 | Fixed | MD=-10.69, 95% CI (-17.26, -4.12), P = 0.001 |
HDL-cholesterol |  | ≥ 50,000 IU/week | 4 | 173 | 0.39 | 0 | Fixed | MD=-4.14, 95% CI (-7.85, -0.43), P = 0.03 |
|  | Treatment duration | < 12 weeks | 3 | 145 | 0.24 | 29 | Random | MD=-4.01, 95% CI (-8.91, 0.89), P = 0.11 |
|  |  | ≥ 12 weeks | 6 | 277 | 0.29 | 18 | Fixed | MD=-9.69, 95% CI (-15.95, -3.42), P = 0.002 |
Changes in | Dose of Vitamin D3 | < 50,000 IU/week | 5 | 249 | 0.26 | 24 | Fixed | MD=-0.92, 95% CI (-0.47, 2.31), P = 0.19 |
LDL-cholesterol |  | ≥ 50,000 IU/week | 4 | 173 | 0.95 | 0 | Fixed | MD=-0.62, 95% CI (-2.11, 0.87), P = 0.42 |
|  | Treatment duration | < 12 weeks | 3 | 145 | 0.88 | 0 | Fixed | MD=-0.58, 95% CI (-2.09, 0.94), P = 0.46 |
|  |  | ≥ 12 weeks | 6 | 277 | 0.34 | 12 | Fixed | MD = 0.84, 95% CI (-0.53, 2.21), P = 0.23 |