Table 3 GRADE assessment of outcome measures
Quality assessment | No of patients | Effect | Quality | Importance | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No of studies | Design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | New Comparison | Control | Relative (95% CI) | Absolute | |||
Changes in fasting blood glucose (Better indicated by lower values) | |||||||||||||
11 | randomised trials | serious1,2 | no serious inconsistency | no serious indirectness | serious3 | none | 308 | 276 | - | MD 2.91 lower (4.78 to 1.04 lower) | ⊕⊕OO LOW | IMPORTANT | |
Changes in insulin (Better indicated by lower values) | |||||||||||||
10 | randomised trials | serious1,2 | no serious inconsistency | no serious indirectness | serious3 | none | 229 | 234 | - | MD 1.98 lower (3.32 to 0.64 lower) | ⊕⊕OO LOW | IMPORTANT | |
Changes in triglycerides (Better indicated by lower values) | |||||||||||||
9 | randomised trials | serious1,2 | no serious inconsistency | no serious indirectness | serious3 | none | 216 | 206 | - | MD 11.01 lower (16.42 to 5.61 lower) | ⊕⊕OO LOW | IMPORTANT | |
Changes in total cholesterol (Better indicated by lower values) | |||||||||||||
9 | randomised trials | serious1,2 | no serious inconsistency | no serious indirectness | no serious imprecision | none | 216 | 206 | - | MD 11.69 lower (15.56 to 7.82 lower) | ⊕⊕⊕O MODERATE | IMPORTANT | |
Changes in VLDL-cholesterol (Better indicated by lower values) | |||||||||||||
5 | randomised trials | serious2 | no serious inconsistency | no serious indirectness | serious3 | none | 135 | 137 | - | MD 2.64 lower (4.5 to 0.79 lower) | ⊕⊕OO LOW | IMPORTANT | |
Changes in HDL-cholesterol (Better indicated by lower values) | |||||||||||||
9 | randomised trials | serious1,2 | no serious inconsistency | no serious indirectness | no serious imprecision | none | 216 | 206 | - | MD 5.85 lower (10.28 to 1.42 lower) | ⊕⊕⊕O MODERATE | IMPORTANT | |
Changes in LDL-cholesterol (Better indicated by lower values) | |||||||||||||
9 | randomised trials | serious1,2 | no serious inconsistency | no serious indirectness | serious3 | none | 216 | 206 | - | MD 0.21 lower (0.81 lower to 1.22 higher) | ⊕⊕OO LOW | IMPORTANT | |