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Table 1 Characteristics of the study population according to status of diabetic retinopathy

From: Dietary iron intake is nonlinearly associated with the risk of diabetic retinopathy in adults with type 2 diabetes

Characteristic

Total Participants

(n = 1172)

Without DR

(n = 814)

With DR

(n = 358)

P value c

Sex, n (%)

   

0.442

Male

594 (50.7%)

406 (49.9%)

188 (52.5%)

 

Female

578 (49.3%)

408 (50.1%)

170 (47.5%)

 

Age, mean (SD), y

63.2 (10.8)

63.0 (10.8)

63.7 (10.8)

0.250

Race/ethnicity, n (%)

   

0.002

Non-Hispanic White

485 (41.4%)

360 (44.2%)

125 (34.9%)

 

Non-Hispanic Black

337 (28.8%)

210 (25.8%)

127 (35.5%)

 

Mexican American

226 (19.3%)

153 (18.8%)

73 (20.4%)

 

Other

124 (10.6%)

91 (11.2%)

33 (9.2%)

 

Education, n (%)

   

0.056

Less than high school

467 (39.8%)

306 (37.6%)

161 (45.0%)

 

High school

308 (26.3%)

224 (27.5%)

84 (23.5%)

 

College or higher

397 (33.9%)

284 (34.9%)

113 (31.6%)

 

Marital status, n (%)

   

0.578

Married or living with partner

726 (61.9%)

509 (62.5%)

217 (60.6%)

 

Not married

446 (38.1%)

305 (37.5%)

141 (39.4%)

 

Poverty income ratio, n (%)

   

0.455

< 1.85

573 (48.9%)

390 (47.9%)

183 (51.1%)

 

1.85 to 3.50

304 (25.9%)

211 (25.9%)

93 (26.0%)

 

 3.50

295 (25.2%)

213 (26.2%)

82 (22.9%)

 

Weight status by BMI, n (%)

   

0.030

Normal or underweight (< 25.0)

152 (13.0%)

107 (13.1%)

45 (12.6%)

 

Overweight (25.0 to 30.0)

332 (28.3%)

212 (26.0%)

120 (33.5%)

 

Obese ( 30.0)

688 (58.7%)

495 (60.8%)

193 (53.9%)

 

Smoking status, n (%)

   

0.052

Never smoker

532 (45.4%)

351 (43.1%)

181 (50.6%)

 

Former smoker

442 (37.7%)

323 (39.7%)

119 (33.2%)

 

Current smoker

198 (16.9%)

140 (17.2%)

58 (16.2%)

 

Alcohol consumption, n (%)

   

0.229

Never drinker

213 (18.2%)

147 (18.1%)

66 (18.4%)

 

Former drinker

179 (15.3%)

115 (14.1%)

64 (17.9%)

 

Current drinker

780 (66.6%)

552 (67.8%)

228 (63.7%)

 

General health status, n (%)

   

0.003

Excellent to good

640 (54.6%)

468 (57.5%)

172 (48.0%)

 

Fair or poor

532 (45.4%)

346 (42.5%)

186 (52.0%)

 

Duration of diabetes, n (%)

   

< 0.001

< 10 years

786 (67.1%)

655 (80.5%)

131 (36.6%)

 

 10 years

386 (32.9%)

159 (19.5%)

227 (63.4%)

 

HbA1c, mean (SD)

7.25 (1.68)

6.94 (1.49)

7.98 (1.86)

< 0.001

HbA1c level, n (%)

   

< 0.001

< 6.5

411 (35.1%)

340 (41.8%)

71 (19.8%)

 

 6.5

761 (64.9%)

474 (58.2%)

287 (80.2%)

 

Blood haemoglobin level, n (%) a

   

0.004

Normal/High

997 (85.1%)

709 (87.1%)

288 (80.4%)

 

Low

175 (14.9%)

105 (12.9%)

70 (19.6%)

 

History of comorbidities, n (%)

    

Hypertension

965 (82.3%)

660 (81.1%)

305 (85.2%)

0.105

Hypercholesteraemia

643 (54.9%)

432 (53.1%)

212 (59.2%)

0.059

Congestive heart failure

123 (10.5%)

64 (7.9%)

59 (16.5%)

< 0.001

Coronary heart disease

138 (11.8%)

88 (10.8%)

50 (14.0%)

0.148

Angina/angina pectoris

97 (8.3%)

64 (7.9%)

33 (9.2%)

0.509

Heart attack

139 (11.9%)

82 (10.1%)

57 (15.9%)

0.006

Stroke

127 (10.8%)

74 (9.1%)

53 (14.8%)

0.005

Dietary iron intake, mg/d, Mean (SD)

13.9 (6.62)

14.3 (6.76)

13.2 (6.24)

0.008

Adequate intake of iron by RDA, n (%) b

   

0.176

Adequate

245 (20.9%)

161 (19.8%)

84 (23.5%)

 

Inadequate

927 (79.1%)

653 (80.2%)

274 (76.5%)

 
  1. Abbreviations: BMI, body mass index (calculated as weight in kilograms divided by height in metres squared); DR, diabetic retinopathy; RDA, recommended dietary allowance; SD, standard deviation
  2. a Blood haemoglobin level was classified according to haemoglobin concentrations for the diagnosis of anaemia and assessment of severity released by World Health Organization in 2011
  3. b Intake recommendations for iron were developed by the Food and Nutrition Board (FNB) at the Institute of Medicine (IOM) of the National Academies (formerly National Academy of Sciences)
  4. c Comparisons were made by the use of the chi-square for categorical variables and the2-sample t test for continuous variables