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Table 3 Stratified analyses for association of dietary iron with diabetic retinopathy*

From: Dietary iron intake is nonlinearly associated with the risk of diabetic retinopathy in adults with type 2 diabetes

Variable

Dietary iron intake, OR (95% CI), mg/d

P value for interaction

 

Quartile 1

(1.81–9.60)

Quartile 2

(9.61–13.1)

Quartile 3

(13.2–18.1)

Quartile 4

(18.2–52.9)

Sex

    

0.471

Male

1 [Reference]

1.22 (0.66–2.26)

0.82 (0.44–1.53)

0.81 (0.44–1.48)

 

Female

1 [Reference]

0.84 (0.49–1.42)

0.44 (0.24–0.81)

0.76 (0.37–1.56)

 

Race/ethnicity

    

0.288

Non-Hispanic White

1 [Reference]

1.05 (0.51–2.15)

0.82 (0.39–1.72)

1.10 (0.52–2.34)

 

Non-Hispanic Black

1 [Reference]

0.79 (0.39–1.59)

0.38 (0.17–0.85)

0.74 (0.31–1.75)

 

Mexican American

1 [Reference]

1.51 (0.61–3.78)

0.61 (0.23–1.61)

0.84 (0.31–2.25)

 

Other

1 [Reference]

0.72 (0.07–7.71)

0.97 (0.09–11.1)

0.01 (0.00-0.55)

 

Weight status

    

0.982

BMI < 30

1 [Reference]

1.20 (0.64–2.24)

0.73 (0.38–1.38)

0.64 (0.32–1.30)

 

BMI > 30

1 [Reference]

0.88 (0.52–1.49)

0.45 (0.25–0.82)

0.82 (0.46–1.46)

 

HbA1c

    

0.841

< 6.5%

1 [Reference]

0.75 (0.34–1.66)

0.56 (0.24–1.32)

0.45 (0.19–1.06)

 

 6.5%

1 [Reference]

1.10 (0.69–1.76)

0.56 (0.34–0.93)

0.90 (0.53–1.53)

 

Duration of diabetes

    

0.422

< 10-y

1 [Reference]

0.95 (0.56–1.61)

0.78 (0.44–1.38)

0.84 (0.46–1.38)

 

 10-y

1 [Reference]

1.08 (0.57–2.07)

0.40 (0.21–0.76)

0.65 (0.33–1.27)

 

Blood haemoglobin

    

0.183

Normal/High

1 [Reference]

0.99 (0.64–1.52)

0.67 (0.42–1.07)

0.81 (0.50–1.32)

 

Low

1 [Reference]

0.57 (0.20–1.65)

0.17 (0.05–0.60)

0.23 (0.06–0.90)

 
  1. Abbreviations: BMI, body mass index (calculated as weight in kilograms divided by height in metres squared); OR, odds ratio
  2. * Analyses were adjusted for age, sex (except for sex stratification), race/ethnicity (except for race/ethnicity stratification), body weight status (except for weight status stratification), duration of diabetes (except for diabetes duration stratification) and medical comorbidity variables (general health condition, history of angina/angina pectoris, congestive heart failure, coronary heart disease, heart attack, hypercholesteraemia, hypertension, and stroke)
  3. Blood haemoglobin level was classified according to haemoglobin concentrations for the diagnosis of anaemia and assessment of severity released by World Health Organization in 2011