Fig. 4

Histopathological findings. A, B, D, E: Hematoxylin and eosin staining. C and F: Immunohistochemical staining for S100. The rectangular section in A corresponds to B and C, whereas that in D corresponds to E and F. A and D: In the right lobe mass lesion, the typical follicular epithelium formed follicular structures with fibrous septa and nodular proliferation, consistent with nodular goiter. B and C: A structure consistent with the resected RLN that appeared severely degenerated by intense inflammation (arrows) was observed just beneath the dissected surface of the thyroid lesion. E and F: Close to B and C, the nerve structure appears markedly disrupted (arrows) and surrounded by dense fibrosis with inflammatory cell infiltration and hemorrhagic necrosis