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Table 3 Association of systemic inflammatory response markers with the odds of amputation

From: Neutrophil-lymphocyte ratio (NLR); an accurate inflammatory marker to predict diabetic foot ulcer amputation: a matched case-control study

 

OR

95% CI

P value

Unadjusted

MPV

1.020

(0.740–1.407)

0.902

NLR

1.436

(1.231–1.675)

< 0.001

PLR

1.004

(1.001–1.007)

0.015

LWR

0.148

(0.062–0.304)

< 0.001

Adjusted*

MPV

1.053

(0.757–1.464)

0.760

NLR

1.509

(1.257–1.811)

< 0.001

PLR

1.004

(1.001–1.007)

0.017

LWR

0.151

(0.063–0.310)

< 0.001

Cutoffs

OR

95% CI

P value

MPV in category

MPV < 9.8

1.00 (reference)

-

-

MPV ≥ 9.8

0.704

(0.330–1.502)

0.364

NLR in category

NLR < 6.08

1.00 (reference)

-

-

NLR ≥ 6.08

13.090

(5.143—33.320)

< 0.001

PLR in category

PLR < 210

1.00 (reference)

-

-

PLR ≥ 210

2.231

(1.066–4.669)

0.033

LWR in category

LWR < 0.1265

1.00 (reference)

-

-

LWR ≥ 0.1265

0.092

(0.038–0.226)

< 0.001

  1. * Adjusted for age, sex, diabetes medications, body mass index, duration of diabetes, and smoking status
  2. OR: odds ratio; CI: confidence interval; MPV: mean platelet volume; NLR: neutrophil-to-lymphocyte ratio; PLR: platelet-to-lymphocyte ratio; LWR: lymphocyte-to-WBC ratio