Predictive value of growth hormone and insulin-like growth factor-1 axis for gestational diabetes mellitus: a prospective cohort study

Table 3 Subgroup analyses of the relationship between IGF-I and GDM

Variables(ng/mL)	Model1	P	Model2	P	Model3	P
Variables(ng/mL)	OR (95%CI)	P	OR (95%CI)	P	OR (95%CI)	P
IGF-1
Q1(< 2.57)	Ref	0.000	Ref	0.000	Ref	0.000
Q2(2.57 ~ 3.88)	1.11(0.493 ~ 2.524)	0.794	0.07(0.027 ~ 0.178)	0.000	1.11(0.448 ~ 2.744)	0.822
Q3(3.88 ~ 6.05)	4.01(1.848 ~ 8.703)	0.000	0.08(0.030 ~ 0.195)	0.000	5.71(2.398 ~ 13.574)	0.000
Q4(≥ 6.05)	12.26(5.190 ~ 28.99)	0.000	0.335(0.141 ~ 0.794)	0.013	15.92(6.119 ~ 41.426)	0.000
P for trend	0.000		0.000		0.000
GH
Q1(< 0.12)	Ref	0.000	Ref	0.001	Ref	0.001
Q2(0.12 ~ 0.38)	3.42(1.615 ~ 7.253)	0.001	3.99(1.771 ~ 8.992)	0.001	3.40(1.560 ~ 7.403)	0.002
Q3(0.38 ~ 0.97)	0.77(0.369 ~ 1.621)	0.497	1.12(0.500 ~ 2.509)	0.782	0.81(0.374 ~ 1.732)	0.579
Q4(≥ 0.97)	0.87(0.419 ~ 1.808)	0.709	0.828(0.380 ~ 1.802)	0.634	0.85(0.398 ~ 1.801)	0.666
P for trend	0.000		0.001		0.001

Abbreviations: FBG Fasting blood glucose; OR, odds ratio; CI, confidence interval
Model 2, adjusted for age and pre-pregnancy BMI
Model 3: further adjusted for Order of birth, history of chronic diseases and history of previous poor pregnancy outcome based on Model 2

ISSN: 1472-6823