Predictive value of growth hormone and insulin-like growth factor-1 axis for gestational diabetes mellitus: a prospective cohort study

Table 4 Subgroup analyses of the relationship between GH and GDM

Variables(ng/mL)	Model1	P	Model2	P	Model3	P
Variables(ng/mL)	OR (95%CI)	P	OR (95%CI)	P	OR (95%CI)	P
GH < 0.77
Q1(< 2.63)	Ref	0.000	Ref	0.000	Ref	0.000
Q2(2.63 ~ 3.79)	0.054(0.17 ~ 0.164)	0.000	0.064(0.020 ~ 0.205)	0.000	0.045(0.014 ~ 0.146)	0.000
Q3(3.79 ~ 5.87)	0.069(0.023 ~ 0.205)	0.000	0.055(0.017 ~ 0.180)	0.000	0.067(0.022 ~ 0.205)	0.000
Q4(≥ 5.87)	0.208(0.072 ~ 0.598)	0.004	0.224(0.074 ~ 0.675)	0.008	0.184(0.062 ~ 0.544)	0.002
P for trend	0.000		0.000		0.000
GH > 0.77
Q1(< 2.46)	Ref	0.002	Ref	0.001	Ref	0.002
Q2(2.46 ~ 4.28)	0.102(0.023 ~ 0.462)	0.003	0.038(0.005 ~ 0.288)	0.002	0.024(0.003 ~ 0.218)	0.001
Q3(4.28 ~ 7.03)	0.057(0.011 ~ 0.302)	0.001	0.038(0.005 ~ 0.271)	0.001	0.033(0.004 ~ 0.252)	0.001
Q4(≥ 7.03)	0.393(0.093 ~ 1.653)	0.202	0.316(0.058 ~ 1.720)	0.183	0.201(0.033 ~ 1.220)	0.081
P for trend	0.002		0.001		0.002

Abbreviations: FBG Fasting blood glucose; OR, odds ratio; CI, confidence interval
Model 2, adjusted for age and pre-pregnancy BMI
Model 3: further adjusted for Order of birth, history of chronic diseases and history of previous poor pregnancy outcome based on Model 2

ISSN: 1472-6823